David. T Felson, MD, MPH, Boston University School of Medicine Clinical Epidemiology Research and Training Unit

We are pleased to highly recommend to you, OAISYS Inc., for measurement of long limb measurements. we contracted with OAISYS and Dr. Cooke to make mechanical axis measurements, bony landmark identification and grading of images of images for arthritis as part of a large, multicenter NIH funded study called the “Multicenter Osteoarthritis Study (MOST)”. OAISYS compiled the data and placed it in a spreadsheet so that we could analyze the data. They did an outstanding job. We tested the reproducibility of their measurements by feeding them back images, without their knowledge, and on repeat measurement, they always got exactly the same answer. They provided us with highly accurate data with no need on our part to clean it of extraneous errors, and they completed the work in time, even though the volume was considerable (over 1500 images). Given the high quality of their work, we are enthusiastic about asking them to do additional work.

Michael Nevitt PhD, John Lynch PhD, Department of Epidemiology and Biostatistics UCSF

In large scale epidemiological studies of knee osteoarthritis, including the Osteoarthritis Initiative, we have used results from OAISYS to examine the role of limb alignment in the development and progression of knee osteoarthritis. his has involved problem free electronic transfer of several thousand images from the Coordinating enter at UCSF in San Francisco to OAISYS. OAISYS have always handled our images in a reliable manner analyzed them promptly and returned a complete set of clean electronic data. They have worked closely with us in helping to improve the quality of image acquisition, and have also been able to successfully extract the needed data from images of suboptimal quality. We continue to use them for large ongoing imaging studies and are enthusiastic about continued collaborations in the future for studies that require this unique measurement.

Leena Sharma MD Professor, Division of Rheumatology, Feinberg School of Medicine, Northwestern University

We were pleased to have OAISYS complete the limb alignment analysis for our MAK-3 project, and highly recommend their work. OAISYS and Dr. Cooke were tasked with measuring several lower limb measurements and angles, such as mechanical axis and knee joint angle. They produced reliable, accurate results for all the project images and returned a complete set of clean, electronic data that we needed in timely fashion. We used the information provided by OAISYS to examine the role of limb alignment in the development and progression of knee osteoarthritis. I was very impressed with OAISYS’s work and look for opportunities to work with them in future projects.

Chad R. Munro CEO of Halifax Biomedical

Having worked for several years in orthopaedic product development, I have trained to identify market opportunities that are based on unmet user needs. There is a strong need to provide orthopaedic surgeons with more information to make clinical decisions. Dr. Cooke and his team at OAISYS Inc. have established themselves as leaders in this field well before this current emerging demand for better clinical measurements. My current company, Halifax Biomedical Inc, was also created to fulfill the need for clinical information as it related to RSA contract research, a specialized promising technique for orthopaedics. During the course of the last year I have had several conversations with Dr. Cooke regarding Orthopaedic Imaging. I find him to have, not only an intimate understanding of the needs with regard to Othopaedic Imaging, but also a clear understanding of how to implement these measurement techniques in a clinical manner. I have no doubt, that no matter what the project, Dr. Cooke and his team will complete the project in a precise and enthusiastic manner.